Model for a Patient-Centered Comparative Effectiveness Research Center

Patient-centered comparative effectiveness research: essential for high-quality care.

Economics of individualization in comparative effectiveness research and a basis for a patient-centered health care.

The United States aspires to use information from comparative effectiveness research (CER) to reduce waste and contain costs without instituting a formal rationing mechanism or compromising patient or physician autonomy with regard to treatment choices. With such ambitious goals, traditional combinations of research designs and analytical methods used in CER may lead to disappointing results. I...

Beyond joint implant registries: a patient-centered research consortium for comparative effectiveness in total joint replacement.

DESPITE THE PROVEN EFFECTIVENESS OF TOTAL joint replacement (TJR) surgery in relieving advanced knee and hip arthritis pain, TJR outcomes have come under intense public scrutiny in recent years. The 2010 recall of ASR metal-on-metal hip implants heightened awareness of the importance for implant safety surveillance for this high-cost and high-use procedure and exposed the need for a national sy...

Comparative effectiveness of prostate cancer treatments for patient-centered outcomes

BACKGROUND In the context of prostate cancer (PCa) characterized by the multiple alternative treatment strategies, comparative effectiveness analysis is essential for informed decision-making. We analyzed the comparative effectiveness of PCa treatments through systematic review and meta-analysis with a focus on outcomes that matter most to newly diagnosed localized PCa patients. METHODS We pe...

Privacy-preserving analytic methods for multisite comparative effectiveness and patient-centered outcomes research.

BACKGROUND For privacy and practical reasons, it is sometimes necessary to minimize sharing of individual-level information in multisite studies. However, individual-level information is often needed to perform more rigorous statistical analysis. OBJECTIVES To compare empirically 3 analytic methods for multisite studies that only require sharing of summary-level information to perform statist...